Suppose you run a dermatology clinic or a busy family practice. You’re looking for a place in New York City that checks all the boxes for a medical tenant—easy accessibility for staff and patients, modern facilities, foot traffic, and a vibrant surrounding community. Where should you look? For starters, you could check out medical buildings near Grand Central Terminal.
Grand Central, of course, is known as a transit hub. So you already have location and accessibility checked off. But beyond accessibility, it’s in the thick of the action. With the constant foot traffic around the terminal, your medical office has a built-in flow of potential patients walking by every day. Plus, this area is teeming with office buildings full of highly paid executives who have robust health insurance or can even pay out of pocket for extra services. This reason alone makes medical buildings near Grand Central Terminal incredibly appealing for any healthcare practice aiming to expand or get a strong start.
With that said, we put together this list of six standout buildings ideal for medical professionals looking into this exciting market.
Finding Your Perfect Medical Office Space Near Grand Central Terminal
Before reviewing our list of the 6 top medical buildings near Grand Central Terminal, let’s review some background info first. We’ll first give you an overview of the neighborhood and transition into some features you’ll want to find in a medical office space.
Grand Central: A Strategic Choice for Healthcare Providers
Grand Central isn’t just a major transit hub—it’s a goldmine for medical practices. Why? Because every day, thousands of professionals, many with top-tier health insurance, work and pass through this area. They’re looking for convenience in everything, including healthcare. Previously, landlords might have hesitated to rent to medical practices due to high traffic and the complexities of medical plumbing. But times have changed. Since 2020, vacancy rates have risen, and landlords are now more than happy to welcome medical tenants. They see the value in the steady foot traffic and long-term leases that healthcare providers bring.
What to Look for in Your Medical Office Space
When checking out potential medical buildings near Grand Central Terminal, you should consider more than just square footage. How about after-hours access? If your patients need to see you on a weekend or after work, that’s something you’ll want to have. Also, does the space allow for installing advanced plumbing? This factor will be vital if your practice involves a lot of specialty equipment, like in dental or dermatology clinics. Don’t forget about power needs, either. You’ll need enough juice to use high-tech tools like lasers for eye treatments. And backup power is also vital—especially for places like fertility clinics, where you need to keep embryos safe in liquid nitrogen no matter what.
The List: 6 Great Medical Buildings Near Grand Central Terminal
Now that we have that background info out of the way let’s get into our list of 6 great medical buildings near Grand Central Terminal.
30 East 40th Street
At 30 East 40th Street, you’ll find a medical office building perfectly designed for healthcare professionals just two blocks from Grand Central Terminal. Whether you’re just starting or looking to expand your practice, 30 East 40th Street offers a supportive environment with established medical and dental practices. Floor plates can come as small as a cozy 500 square feet to accommodate smaller medical practices. Others can be as expansive 3,500 square feet. It’s home to a diverse group of tenants, including Norman Marcus Pain Institute, Cosmopolitan Dental, Philip D. Pack, Boston Orthotics & Prosthetics, Pediatric Ophthalmology-NY, and more.
From the moment your patients walk into the recently updated lobby, they’ll feel welcomed by attentive staff that sets a positive tone for their visit. The building’s quick, high-speed elevators whisk them straight up to your office, minimizing wait times and making appointments smoother for everyone involved. Additionally, with 24-hour access, you can run your practice on your schedule, making it as flexible as you need.
Sample Floor Plan: Partial PENT Floor – Suite 1302 (Courtesy of CoStar)
Check out the penthouse office at 1302, a versatile medical space available for direct lease. It spans 3,440 square feet, with options to divide down to as little as 544 square feet, tailored to fit your needs. At $64.00 per square foot, this space is vacant with negotiable lease terms, in average condition, and fully built-out.
20 East 46th Street
Are you in search of a modern medical office that’s both central and convenient? Take a look at 20 East 46th Street. Located between Fifth and Madison Avenues and a quick stroll from Grand Central Terminal, this building is an ideal spot for healthcare professionals. Omni Eye Services, Dr. Gerard Varlotta, DO, FACSM, Sue Decotiis, MD, INVO Pain Medicine Group, and 20 East Medical are the largest tenants here. However, many other professionals practice here and benefit from the location and tailored facilities for a wide range of medical specialties.
24/7 access, an attended, freshly renovated lobby, new elevators, and a top-notch air conditioning system are just the start. You’ll also be in good company here, joining a diverse group of medical specialists who appreciate the upgraded bathrooms and hallways, which add class to the building. It’s the perfect setting for any medical practice looking to thrive in a professional environment that patients can easily reach.
Sample Floor Plan: Partial 3rd Floor – Suite 302 (Courtesy of CoStar)
The office space in Suite 302 on the 3rd floor is a spacious 3,915-square-foot area designed for medical use. In addition, it’s available for direct lease. However, pricing is only available upon inquiry, The space is currently vacant with flexible lease terms.
6 East 39th Street (The Craftsmen Building)
Check out 6 East 39th Street, also known as The Craftsman Building. This medical building near Grand Central Terminal is perfect for anyone who needs easy access to the city. Moreover, the building is a piece of history, built in 1913 by Gustav Stickley. However, if the age concerns you, don’t worry—it’s got all the modern comforts you need, including a recently revamped lobby.
Wen Gu, PhD, Summit Dental Laboratory, Therapists of New Yoro, Human Artists, MD are the largest medical tenants here, and the offices are spacious—many are over 2,000 square feet. Moreover, it’s possible to fit available offices with private bathrooms, an ideal perk for potential medical use. Additionally, with 24-hour access and reliable air conditioning, you can ensure your practice operates smoothly around the clock.
*There is availability but no floor plan samples*
110 East 40th Street
If you’re searching for the perfect medical office building near Grand Central, 110 East 40th Street should be at the top of your list. Right in the heart of Manhattan, between Lexington and Park Avenues, this building combines old New York charm with all the modern features you need for a bustling medical practice. Constructed in 1916 and revamped in 2009, it offers large, light-filled offices that look out over Park Avenue and a picturesque fountain—adding a bit of tranquility to your busy day.
What’s great about 110 East 40th Street is how easy it makes life for your team and patients. Just two blocks from Grand Central, your commute and accessibility are straightforward. The building has 24-hour security, air conditioning, and new, energy-efficient windows that keep the city’s hustle at bay. With spaces designed to be as functional as they are inviting, this spot is ready to support your practice’s growth and success. Qral Group is the largest tenant here and is more biotech and investment-focused. Many dental practices, such as Expert Dental, PC, Advanced Periodontics & Implant Dentistry, and Abelson & Minsky Dental Group, also work here.
*There is availability but no floor plan samples*
369 Lexington Avenue
Located just two minutes on foot from Grand Central Terminal, 369 Lexington Avenue offers immediate accessibility. However, it’s a top pick for healthcare professionals for many other reasons. Its 28 stories and 153,412 square feet combine historic charm with modern amenities and features that cater to medical practices. High ceilings and abundant natural light create a welcoming atmosphere for patients. At the same time, 24-hour access, high-speed Wi-Fi, and concierge services keep your practice running smoothly.
Finally, luxury upper-floor spaces with balconies make it a prime spot for high-end clinics and wellness centers. All Care Fertility Center is the largest medical tenant here. Others, such as Cryobank, Grand Central Pain Relief Center, Dr. Will Chiropractic, and Network Spine, also call it home.
Sample Floor Plan: Partial 28th Floor – Suite PH (Courtesy of CoStar)
This penthouse unit is a fully built-out, 2,659-square-foot office space for $43.00 per square foot. It’s vacant and offers an excellent opportunity for a fresh start with a three-year lease term.
315 Madison Avenue
315 Madison Avenue is a prime choice for medical office space near Grand Central Terminal and steps from Bryant Park, Times Square, and the Theater District. Office spaces at 315 Madison Avenue are well-maintained and cater to businesses of all sizes, featuring high-speed internet and tenant-controlled air conditioning. Moreover, a brand new lobby will be completed by mid-2024.
The building provides essential amenities for medical tenants like Manhattan Center For Cognitive Behavioral Therapy, New York Podiatric Medicine & Surgery PC, Dr. Irvind Khurana, Lamb Chiropractic, and Abbott Mental Health Counseling. Firstly, there’s 24/7 access. There’s also a lobby attendant, on-site cleaning and maintenance, and a superintendent always on hand. What’s more, commuting is a breeze with immediate access to subway trains, bus lines, and underground parking.
Sample Floor Plan: Partial 4th Floor – Suite 407 (Courtesy of CoStar)
This office space on the 4th floor at 407 is a spacious 2,596 square-foot area available for direct lease at $50.00 per square foot plus electricity. Furthermore, the space is currently vacant, and the lease terms are negotiable.
Final Words
Choosing the right location for your medical practice is key, and these medical buildings near Grand Central Terminal offer some of the best options in New York City. Whether you value modern amenities, historic charm, or simply a prime location that makes it easy for both staff and patients to access, these buildings have it all. Hopefully, this piece gave you valuable insights to make your next big move count.
